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physician, Dr, Alliance College of Medical Science
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4 Nov 2009, 10:20
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Volume 6, Issue 4, Pages 179-187 (April 1995) 5 of 7 ABSTRACT ABSTRACT + REFS FULL-TEXT PDF (1267 KB) CITATION ALERT CITED BY RELATED ARTICLES EXPORT CITATION EMAIL TO A COLLEAGUE RIGHTS/PERMISSIONS NEED REPRINTS? BOOKMARK ARTICLE FULL TEXT ELSEWHERE Both dietary 18:2 and 16:0 may be required to improve the serum LDL/HDL cholesterol ratio in normocholesterolemic men Kalyana Sundram1, K.C. Hayes2, Othman H. Siru3 Received 2 June 1994; accepted 23 November 1994.
Abstract In a double-blind crossover study, 23 healthy normocholesterolemic mals volunteers were fed carefully designed whole food diets enriched by oleic acid (canola, CAN), palmitic acid (palm olein, POL), or an American Heart Association Step 1 fat blend (AHA)_. Resident males received each diet during three consecutive 4-week periods. The diets supplied approximately 31% energy as fat and <200 mg of cholesterol/day. The percent energy (% en) from each dietary fatty acid was strictly controlled to compare low-16:0, high-18:1 (CAN) or high-16:0, low-18:2 (POL) intake with a balanced intake of each (AHA). The first two diets represented direct exchange of 7% en between 18:1 + 18:2 (CAN) and 16:0 (POL), whereas the main difference between POL and AHA was <4% en exchanged between 16:0 and 18:2. Serum total cholesterol (TC), very low density lipoprotein cholesterol (VLDL-C), and LDL-C were not significantly affected by the three diets despite manipulation of these key fatty acids. However, both CAN (low saturates [SATs], high monounsaturates [MONOs]) and POL (high SATs, low polyunsaturates [POLYs]) depressed HDL-C significantly (?8 mg/dL) relative to the AHA (mod SATs, mod POLYs) diet. Consequently, the AHA diet increased HDL3-C and lowered the LDL/HDL cholesterol ratio significantly relative to the CAN and POL diets. Neither serum Lp(a), apoA1, nor apoB were affected by diet. These data support the previous observation that in normolipemic humans consuming a moderate fat load (<31% en) low in myristic acid (14:0) and dietary cholesterol, the effect of palmitic acid (16:0) on TC and the LDL/HDL ratio is comparable to that of monounsaturated oleic acid (18:1), Furthermore, a definite intake of POLYs and SATs may be essential for maximizing HDL3-C under these conditions. Keywords: fatty acids, palmitic, oleic, lipoproteins, cholesterol, humans No full text is available. To read the body of this article, please view the PDF online. a Palm Oil Research Institute of Malaysia (PORIM), Kuala Lumpur, Malaysia b Foster Biomedical Research Laboratory, Brandeis University, Waltham MA, USA c Armed Forces Medical Corps, Kementah, Kuala Lumpur, Malaysia Address reprint requests to Dr. K. Sundram, PORIM, P.O. Box 10620, 50720 Kuala Lumpur, Malaysia. PII: 0955-2863(95)00029-Y © 1995 Published by Elsevier Inc. 5 of 7 Copyright © 2009 Elsevier, Inc. All rights reserved | Privacy Policy | Terms & Conditions | Feedback | About Us | Help | Contact Us | The content on this site is intended for health professionals. I was personally involved in this study comparing palm oil vs soya bean oil. Please feel free to contact me via e-mail for further detail of the study.
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